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- THE WEEK, Page 23HEALTH & SCIENCEAny Way You Slice It
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- A leading researcher unsheathes a new weapon in the fight against
- AIDS
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- Despite millions of dollars and the efforts of some of the
- best minds in medicine, the search for an AIDS vaccine has yet to
- yield an effective cure. Now one of the world's leading AIDS
- researchers wants to try a new weapon: a "molecular knife" that
- disables the virus by slicing up its genetic code.
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- Flossie Wong-Staal, who rose to prominence at the U.S.
- National Cancer Institute, reported last week that a
- hairpin-shape enzyme derived from a plant virus has shown a
- remarkable affinity for the virus that causes AIDS. Like the
- chemical scissors used in gene splicing, the hairpin enzyme
- hooks onto the virus' RNA and snips it into pieces. Introduced
- into a test-tube culture of AIDS-infected blood cells, it slowed
- the spread of the virus 70% to 90%.
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- Safety tests on actual AIDS patients won't begin before
- next year, says Wong-Staal, now at the University of
- California, San Diego. But if it works for one strain of AIDS,
- it could be easily modified to work for another -- or any other
- viral disease, for that matter, from hepatitis to herpes.
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